I tried to post a response days ago but couldn't due to Tribe's glitches--but I feel it's important to give you some info on these. In most vet offices that keep up with developments in the field (and there are plenty that do not), they don't pressure you to give vaccines any more due to the huge problems (and deaths from sarcoma) that occurred beginning with the introduction of the 4-in-1 and 5-in-1 (including leukemia) vaccines. They now no longer recommend annual boosters and it is NOT considered good medicine any more. If you do shots (like an initial series of shots, followed by boosters no more than once or twice in the cat's lifetime), they have protocols issued now where they want you to break them out into separate shots, put into separate specified places on the cat's body. No more than a 3-in-1 should be used, with rabies separate, and leukemia separate, and preferably don't even do these all on the same day. A lot of places do force you to have rabies shots. So it really depends on what vet you use: many will still demand shots first time they see a cat, because that is their bread and butter. (I am calling it what it is.) The best vet hospital in the area used to send out annual reminders, used to bug you about boosters every time you brought in your cat -- but after a number of fatalities (including my dear Pumpkin), they don't do that any more. In fact I had TWO cats get sarcoma at the injection site (nape of neck) but one did survive. This is really important info. for all cat owners, but only professional animal people seem to have gotten the news so far. But they revised the recommendations and protocols almost 10 years ago now.